Our process chemistry teams deliver safe, scalable execution of complex and high-hazard reactions under validated, GMP-aligned conditions. With specialized reactor systems, advanced containment, and rigorous process safety management, we support demanding pharmaceutical intermediate and API synthesis from development through commercial scale.
Core Reaction Capabilities
- Hydrogenation & Reduction Chemistry
High-pressure hydrogenations and reductions using catalytic systems and strong hydride reagents (e.g., LAH, borane complexes) with precise thermal and pressure control.
- Oxidation Chemistry
Controlled oxidations using pure oxygen under pressure, peroxide-based systems, ozonization, and other high-energy oxidation processes.
- Halogenation & Halogen Chemistry
Bromination, chlorination, fluorination, and related transformations, including controlled chlorinations and reactions involving hydrofluoric acid solutions.
- Metal-Catalyzed & Coupling Reactions
Transition-metal-catalyzed couplings and related bond-forming reactions critical for complex pharmaceutical scaffolds.
- Organometallic & Strong Base Chemistry
Reactions involving highly reactive species such as tert-butyllithium, Grignard reagents, sodium hydride, and other air- and moisture-sensitive systems.
- Nitration & High-Energy Reactions
Execution of nitrations and other energetically sensitive transformations with comprehensive thermal hazard and runaway risk controls.
- Amination & Diazotization Chemistry
Aminations, diazotization–oxidation sequences, and azide-based transformations using sodium azide under strictly controlled conditions.
- Cyanation Chemistry
Cyanations employing sodium or potassium cyanide with dedicated containment, monitoring, and waste management systems.
- Sulfonation & Alkylation
Industrial sulfonation and alkylation reactions for functional group installation at scale.
- Polymerization Processes
Industrial-scale polymerizations with tight control of molecular weight, heat release, and reaction kinetics.
- Electrochemical & Gas-Phase Processes
Electrolytic reactions, including chloro-alkali processes, photogasification, and controlled gas-phase operations.
- Specialty & Hazardous Reagent Handling
Safe handling of phosgene, ammonia, corrosive reagents, deep cryogenic reactions, and processes requiring extreme temperature control.